Regeneration Matrix

A biomaterial for regenerating multiple tissues in accordance with the original organization and layering of the tissue.

NWL’s Regeneration Matrix™ (RMx™) is the only known product that can regenerate multiple tissues at once, and in accordance with the original organization and layering of the tissues. Thus this novel product can target severe injuries with significant tissue loss that have no other current medical remedy, including major surgical procedures (e.g. tumor removal, orthopedic surgeries), spinal cord injury and some degenerating CNS tissue diseases, that represent markets of huge revenue potential.

RMx™ is a biomaterial matrix that works by local surface contact. It is 100% biocompatible and degrades naturally during the regeneration process. RMx™ can be placed or injected from a syringe and takes the shape of the cavity where it is placed; it sticks to tissue and can hold metal parts (as used e.g. in bone fractures) in place.

As opposed to many biomaterials that are designed with a 2-dimensional architecture that is only layered / formed into 3-dimensions (ex. collagen and fibrin gels, etc.), RMx™ is truly 3-dimensional allowing proper 3-dimensional growth and regeneration.

PRODUCT INDICATIONS STAGE
Regeneration Matrix™:
Multi-tissue regeneration with recreation of the native organizational structure
CNS Regeneration Under Development by:
Regeneration Matrix™:
Multi-tissue regeneration with recreation of the native organizational structure
Tissue loss
Filling of surgically removed tissue (incl. tumors)
Traumatic wounds
GLP work concluded
Preparation for device clinical trials
Compassionate Use
3D Living Scaffold:
In-vitro 3D tissue model, reconstructed 3D tissue implant
Tissue replacement and regeneration
In vitro tissue models
Development
Artificial 3D multi-layered scaffold:
Aiding organization of implanted/ endogenous cells in regeneration process
Tissue regeneration
Drug delivery
Development

Based on studying salamanders and the molecular basis of their unique ability to regrow complex tissues (e.g. limbs, spinal cord), NWL searched for new ways to grow CNS tissue in brain and spinal cord, ultimately resulting in a new material created from blood tissue that supports complex tissue growth and correct organization of multiple tissues, which was the basis for RMx™ and associated products.

RMx™ has had unparalleled success in in vitro and in vivo models: It has been able to regrow / regenerate spinal cord, brain and muscle tissue, as well as dermis and hair follicles (a wealth of data is available).

NWL has completed a comprehensive GLP package for RMx™ that confirmed the product as completely safe. Additional main benefits were found, including inhibition of potential tumor growth (a great asset in any product of this kind) and hindering scar formation. RMx™ is being prepared for device clinical trials.

In the 3-dimensional human body, physical properties and structure are much more important than in a 2-dimensional environment (ex. in a petri dish). 3-dimensional regeneration is significantly affected by physical properties such as mechanical forces, basement membrane architecture and 3D guidance channels / scaffolds1 – and these are usually more important than the surrounding chemical properties (ex. effect from drugs).

The most powerful regenerating vertebrates are the urodeles (salamanders and newts), especially the axolotl that is able to regrow limbs and other body parts throughout its entire lifetime. Interestingly axolotls rarely get cancer, and generally animals with greater regeneration capacity have a lower incidence of tumor growth2.

The key to the urodeles’ powerful regeneration capacity is the formation of the “blastema” at the site of injury. The blastema starts off with a transient matrix that acts as a guidance structure for cells (also mechanically acting through cell surface properties) at the site of injury, and helps with the correct organization of the healing and growing tissue3; if this matrix Is replaced by collagen or some other dense ECM as the physical substructure, regeneration is hindered4.

One of the best 3-dimensional biomaterials for tissue regeneration would thus be expected to be a bioabsorbable 3D matrix with structural and physical similarity to the matrix of a blastema.


1 Baddour et al., 2012; Bhatia, 2010; Calve et al., 2010; Macaya and Spector, 2012; McCreedy and Sakiyama-Elbert, 2012; Pioletti, 2011; Smith et al., 2009; Song and Ott, 2011; Straley et al., 2010; Wang et al., 2011; Zhong et al., 2010.
2 McCusker and Gardiner, 2011; Oviendo and Beane, 2009; Roy and Gatien, 2008.
3 Calve et al., 2010; Ferris et al., 2010; Lévesque et al., 2010; Mariani, 2010; McCusker and Gardiner, 2011; Roy and Gatien, 2008; Santosh et al., 2011; Whited et al., 2011; Wicker and Kamier, 2009; Witman et al., 2011; Zukor et al., 2011.
4 Satoh et al., 2012; Seifert et al., 2012

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